A Look Into the Human Genome Project :: Science Technology Genetics Papers

A Look Into the Human Genome Project Would people buy a set of books that repeated the same four letters in random order page after page? Or would this information be more convenient to the public if on a computer disc? Many people would agree with the idea that this set of books would be boring. Surprisingly, America and the rest of the world are buying the information in this set of books. In fact, these books contain the human genome. The mapping of the genome (or writing this set of books) is a 15-year project that has brought many ethical issues to attention. History of the Human Genome Project The United States Department of Energy and the National Institutes of Health joined forces in 1990 to kick off a 15-year effort to reach two goals: Catalog the genes in human DNA Determine the three billion bases (the four letters in the set of books) in human DNA that encode for genes (U.S. Dept. of Energy 1998). On the international level, the Human Genome Organization (HUGO) was founded. Their goal is to encourage trading of research findings and techniques (National Reference Center 1998). From the national standpoint it brings back memories of The Manhattan Project. Internationally, this cooperation is unprecedented (Shinn 1996). Before the organization of the Human Genome Project, the Department of Energy had biologists and physicists studying the Hiroshima survivors. From this data a GenBank was made. This was the first database for DNA sequences (Gert, et al. 1996). Watson, who won the Nobel prize for his discovery of the double helix, was appointed as the first director of the Human Genome Project. He appropriated three percent of his budget to ethical, legal, and social issues (ELSI) involved with the project (Shinn 1996). Even from the beginning it was anticipated that this project could have both positive and negative outcomes. One goal to be reached after five years was to have markers every ten centimorgans (Gert, et al. 1996). This goal was stated in 1991 and achieved in 1994 - a year ahead of schedule - when a map with markers every two to five centimorgans was published (Casey, et al. 1995). Sequencing would then follow with a focus on areas of disease and in reducing human error. The main goal for the next five years would be markers every one centimorgan (Gert, et al. 1996). Technical Aspects Ideally, the final map will have both physical and genetic information.